Over age 35? You are definitely going to want Microneedling with exosomes
by Dr Caroline Warden NHS GP, cosmetic dermatology and aesthetic doctor in Hale, Cheshire
If you’ve been hearing about “exosome facials” or “microneedling with exosomes” and wondering what’s hype versus science, you’re not alone. This new wave of regenerative skincare has taken the aesthetics world by storm and for good reason. As a doctor-led aesthetic clinic in Hale, Altrincham I only introduce treatments once the data, safety and results truly align.
In this guide, I’ll explain what exosomes are, why I use Purosomes™ in my clinic, what the current scientific evidence shows, what to expect during microneedling, and how this combination can help rejuvenate your skin naturally and safely.
What Are Exosomes?
Exosomes are tiny biological messengers (30–150 nm) naturally released by cells to communicate with each other. Think of them as microscopic “delivery parcels” carrying beneficial cargo such as proteins, peptides, lipids, and genetic signals that can influence nearby cells to repair, regenerate and calm inflammation.
In the context of skin health, exosomes have been shown in laboratory studies to:
Stimulate fibroblast activity and collagen production
Support wound healing and barrier restoration
Reduce oxidative stress and inflammation
Improve hydration and elasticity
When used in combination with controlled skin stimulation techniques like microneedling, they can help signal the skin to heal faster and remodel more effectively.
Why Combine Exosomes with Microneedling?
Microneedling works by creating tiny, controlled punctures in the skin’s surface. These micro-channels trigger a natural healing response, stimulating collagen and elastin production, the two structural proteins that keep our skin firm, smooth and youthful.
However, the process also temporarily opens microscopic pathways that allow regenerative ingredients (such as exosomes) to reach the deeper layers of the skin. When exosomes are applied immediately after microneedling, they act as biological amplifiers, boosting healing and collagen remodelling.
The Scientific Evidence
Although exosome-based skincare is still an emerging field, several peer-reviewed studies have shown promising results:
A randomised split-face study (J Cosmetic Dermatology, 2023) found that microneedling combined with adipose-derived stem-cell exosomes significantly improved wrinkles, hydration, pigmentation and elasticity compared to microneedling alone.
A case series (Plastic & Reconstructive Surgery – Global Open, 2025) reported visible improvement in pore size and skin texture after three sessions of microneedling with exosomes, with no adverse effects and results maintained for over 20 weeks.
A pilot study in melasma patients (Applied Sciences, 2024) showed that 90% of participants experienced a measurable reduction in pigmentation when exosomes were combined with microneedling.
The research consistently indicates that exosomes can enhance outcomes and accelerate recovery — but larger trials are still needed.
Why I Use Purosomes™
At Dr Caroline Warden Skin & Aesthetics in Hale, I use Purosomes™, an advanced form of exosome therapy developed by Dermafocus in Italy. These are not synthetic or human-derived; instead, they are purified from bovine (cow) colostrum, the nutrient-rich “first milk” produced by cows shortly after giving birth.
What Are Purosomes™ Made From?
Bovine colostrum naturally contains growth factors, cytokines, peptides and extracellular vesicles (exosomes) that support repair and regeneration. Dermafocus collects colostrum ethically from grass-fed cattle within hours of calving only after the calves have received their essential share. The remainder undergoes a strict purification process known as AMPLEX Plus™, which isolates the exosomes and removes unwanted proteins, fats, and impurities.
Each vial of Purosomes™ contains billions of purified extracellular vesicles plus a blend of growth factors and antioxidant enzymes designed to:
Stimulate cellular renewal
Enhance collagen synthesis
Reduce inflammation and redness
Promote faster recovery after microneedling
Why I Chose Purosomes™
UK-compliant and safe
Purosomes are non-human derived and therefore permitted for cosmetic use in the UK, unlike human-origin exosomes, which are currently banned in aesthetic treatments.Scientifically consistent
Each batch is manufactured under sterile, controlled laboratory conditions, ensuring a reproducible concentration and purity of exosomes.Synergistic with microneedling
Their nanosized structure allows them to penetrate efficiently through the micro-channels created during needling, delivering regenerative signals directly where they’re needed.Ethical sourcing
Animal welfare is prioritised; calves receive the colostrum they need first, and the product carries Halal and Kosher certification.Excellent for sensitive skin
Purosomes help calm inflammation and strengthen the skin barrier, making them ideal for patients with rosacea-prone or eczema-prone complexions who need gentle yet effective rejuvenation.
Patient Suitability and Considerations
Not suitable for vegans (animal-derived origin)
Caution for severe dairy allergies, although the purification process minimises residual proteins
Suitable for most skin types, including sensitive, provided the barrier is intact
Discuss religious or ethical preferences during consultation to ensure full informed consent
Transparency is central to my approach. Every patient is briefed about the source, safety profile and expectations before treatment.
What Microneedling with Purosomes™ Involves
Microneedling with Purosomes™ is performed entirely in-clinic by myself i.e medical supervision. Here’s what to expect at your appointment in Hale:
1️⃣ Consultation and preparation
We begin with a detailed medical and skin assessment, including your goals, sensitivities, and lifestyle. I’ll determine the correct needle depth (usually 0.5–1.5 mm) and whether a regenerative approach is right for your skin.
2️⃣ Cleansing
Your skin is cleansed and disinfected.
3️⃣ Microneedling procedure
Using a precision medical device, I create controlled micro-channels across the skin’s surface. Most patients describe the sensation as a light vibration or prickling. Occasionally mild pinpoint bleeding may occur and is completely normal.
4️⃣ Application of Purosomes™
During and immediately after microneedling I apply the Purosome serum while the micro-channels remain open. This allows the nanovesicles to penetrate deeply, initiating the regenerative cascade within the dermis.
5️⃣ Soothe and protect
Skin may appear slightly pink for up to 24-48 hours
Exosome Microneedling: Key Benefits for 35+ Skin
| Benefit | Impact (0–10) | Notes |
|---|---|---|
| Collagen boost | 9 | Supports firmer, thicker-looking skin over time. |
| Fine lines & wrinkles | 8 | Softens appearance of early lines; best in a short series. |
| Skin texture & pores | 8 | Smoother feel and more refined look as skin remodels. |
| Firmness & elasticity | 8 | Improves spring and support with cumulative treatments. |
| Radiance & glow | 7 | Brighter tone and renewed luminosity. |
| Downtime (lower is better) | 2 | Typically low: pinkness 24–48h; minimal peeling. |
Higher numbers indicate stronger expected impact based on typical outcomes; downtime shown as a lower number because less is better. Results vary by skin, plan, and number of sessions.
What to Expect Afterwards
| Timeframe | What Happens |
|---|---|
| 0–24 hrs | Skin feels warm and tight; redness is normal. Avoid makeup and active products. |
| 24–72 hrs | Slight dryness or flaking; use gentle cleanser and a hydrating barrier cream. |
| 1–2 weeks | Noticeable glow, smoother texture, and more even tone. |
| 4–6 weeks | Collagen remodelling becomes visible; fine lines and pores refine. |
| 8–12 weeks | Peak results — firmer, clearer, rejuvenated skin. |
Recommended Treatment Course
For optimal, cumulative results:
3 sessions, each spaced 4 weeks apart
Maintenance every 6 months, depending on your goals
Because results rely on collagen synthesis, the effects build gradually and naturally. This makes it an excellent option for those wanting a subtle, authentic improvement rather than an “overdone” look.
Case Study — Microneedling with Purosomes™
Patient profile: 38-year-old female from Cheshire with melasma, visible pores, and mild skin sensitivity.
Treatment plan: Three, monthly sessions of microneedling (0.5–0.75 mm) combined with Purosomes™ application. Homecare included gentle cleansing, daily SPF 50, and barrier-repair moisturiser.
Results at 12 weeks:
Reduced pore visibility and smoother texture
Evened skin tone and lighter melasma patches
Minimal downtime (24–36 hours of mild redness)
Patient feedback: “My skin feels calmer and fresher — like it’s finally balanced.”
(Individual results vary; this case is representative of typical outcomes in compliant skin.)
Risks and Downtime
Microneedling with Purosomes™ is very safe when performed by a medical professional. Potential side-effects include:
Temporary redness, mild swelling or tightness
Pinpoint bruising (resolves within days)
Rare infection if aftercare is neglected
Minimal risk of pigmentation when SPF is used diligently
Following the prescribed skincare routine and avoiding makeup, saunas and exercise for 24 hours will support optimal healing.
FRQUENTLY ASKED QUESTIONS: FAQs
Is Purosomes™ the same as stem-cell exosomes?
No. Purosomes™ are derived from bovine colostrum, not human or stem-cell cultures. They’re purified and cell-free, offering regenerative benefits without the ethical or regulatory issues of human-derived products.
How soon will I see results?
Most patients notice improved luminosity and hydration within two weeks, with ongoing collagen remodelling for over 8–12 weeks.
Is it safe for rosacea-prone skin?
Yes — when performed gently and under medical supervision. The anti-inflammatory properties of Purosomes™ often help calm redness and sensitivity.
Can I wear makeup after microneedling?
Avoid for at least 24 hours. Once the skin has settled, mineral or non-comedogenic makeup can be used.
Are there any lifestyle restrictions?
Avoid intense exercise, heat, alcohol and active skincare for 24–48 hours post-treatment.
Use SPF 50 daily to protect your results.
Why Choose a Doctor-Led Clinic in Altrincham, Cheshire?
Microneedling with exosomes is a medical-grade treatment and should only be performed by trained professionals. At Dr Caroline Warden Skin & Aesthetics, every procedure is carried out in a sterile, clinical setting using products sourced directly from authorised pharmacies and verified distributors.
Your treatment plan is always bespoke, combining evidence-based protocols with your skin’s unique biology for results that look fresh, natural and timeless.
Ready to Experience the wonders of microneedling with exosomes in Altrincham?
Book now for a consultation
Dr Caroline Warden is an experienced NHS GP and aesthetic doctor. She has been a medical doctor for over 18 years. Her main Skin and Aesthetic Clinic is located in Hale, Cheshire but she also runs clinic in Disley, Stockport.
Whether you're new to aesthetic treatments or ready to refine your routine, her bespoke skin assessments are the best place to start. She’ll design a tailored plan based on your skin goals, lifestyle, and timeline.
Book your consultation at the clinic in Hale, Cheshire and experience aesthetic medicine.
You’ll be guided through your medical history, goals, and expectations so you can make an informed choice.
Our main Hale clinic is local To:
Alderley Edge, Altrincham, Bowdon, Bramhall, Hale Barns, Knutsford, Manchester, Mobberley, Sale, Timperley, Urmston, Wilmslow, Handforth, Poynton, Cheadle, Didsbury, Warrington
Our satellite Disley clinic on Thursday nights at Scott, Skin & Co, is local to:
New Mills, High Lane, Marple, Mellor, Whaley Bridge, Hayfield, Stockport
